反应 #64955

反应方程式

3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane

benzylmethylamine

→

trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

溶剂

dioxane

water

反应条件

后处理

1. 1
   萃取The mixture is extracted with CHCl3
2. 2
   干燥the extracts are dried with K2CO3
3. 3
   浓缩concentrated
4. 4
   workup.DISTILLATIONdistillation up to 160° C. (oil bath temperature)

实验过程

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

来源