反应 #64935

反应方程式

1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine

sodium hydroxide

→

8-Benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

溶剂

sulphuric acid

water

反应条件

后处理

1. 1
   其他the sodium sulphate which has precipitated
2. 2
   过滤is filtered off with suction
3. 3
   萃取the filtrate is extracted with chloroform
4. 4
   干燥The extract is dried over potassium carbonate
5. 5
   浓缩concentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

实验过程

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

来源