反应 #64832

ord-b21f295b723640c999e6fa015768ecb3

反应方程式

O=C(O)CC(O)C(=O)O
malic acid
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
gluconic acid delta-lactone
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C([O-])CC(O)(CC(=O)O)C(=O)O.[Na+]
monosodium citrate
O=C([O-])CC(O)C(=O)[O-]
malate

反应物

O=C(O)CC(O)C(=O)O
malic acid
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
gluconic acid delta-lactone
O=C([O-])O.[Na+]
sodium bicarbonate

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他to react

实验过程

Process: Apply crystallized citric acid, then heat to 60° C. and wet with 36 ml of gluconic acid delta-lactone solution (10 parts of gluconic acid delta-lactone to 5 parts of water); apply malic acid, then allow sodium bicarbonate I to react to give monosodium citrate and malate and then allow sodium bicarbonate II, calcium carbonate and potassium bicarbonate to undergo partial reaction (partial conversion to the citrate). Then cover the surface with citric acid powder. Finally allow sodium carbonate to undergo partial reaction, and dry in vacuo. This effervescent base is mixed with 500 parts of aspirin and with corresponding additives.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05415870uspto-grants-1995_05