反应 #64590

反应方程式

hydrochloric acid

chloride

THF

Anthranilic acid

pyridine

tetrahydrofuran

→

N-n-octanoylanthranilic acid

收率 79.4%

反应条件

后处理

1. 1
   workup.ADDITIONwas added to the reaction mixture
2. 2
   过滤Pyridine hydrochloride was filtered
3. 3
   其他the solvent was removed

实验过程

Anthranilic acid was dissolved in a mixed solvent containing pyridine and tetrahydrofuran (THF) in 5:5 ratio and a THF solution of n-caprioyl chloride was dropped to the solution during several hours for reaction. After the reaction, hydrochloric acid was added to the reaction mixture. Pyridine hydrochloride was filtered and the solvent was removed. N-n-octanoylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 79.4%.

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