反应 #6459

反应方程式

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide

Trifluoroacetic anhydride

→

2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile

收率 96.9%

溶剂

hydrochloric acid

pyridine

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   其他The extract was dried
3. 3
   浓缩concentrated
4. 4
   其他to leave a residue, which
5. 5
   其他was purified by column chromatography on silica gel

实验过程

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide (3.77 g) was dissolved in pyridine (5.53 g). The solution was cooled to 0° C. Trifluoroacetic anhydride (4.40 g) was added dropwise. The mixture was stirred for 2 hours at 0° C., and then diluted with dil. hydrochloric acid and extracted with ethyl acetate. The extract was dried and concentrated to leave a residue, which was purified by column chromatography on silica gel to obtain 2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile (3.41 g).

来源