反应 #6411

反应方程式

sodium hydroxide

8-bromo-1-octene

ethyl p-hydroxybenzoate

potassium carbonate

hydrochloric acid

→

p-(7-octenyloxy)benzoic acid

收率 89.0%

溶剂

water

ethanol

反应条件

后处理

1. 1
   workup.ADDITIONThereto added
2. 2
   温度reflux
3. 3
   其他After conclusion of the reaction
4. 4
   其他The generated precipitate was collected
5. 5
   洗涤washed sufficiently with water
6. 6
   其他dried
7. 7
   其他to obtain 10.8 g of the objective ether compound

实验过程

9.4 g of 8-bromo-1-octene, 9.0 g of ethyl p-hydroxybenzoate, and 7.6 g of potassium carbonate were refluxed in ethanol for 10 hours. Thereto added was an aqueous solution containing 2.4 g of sodium hydroxide, and then reflux was further continued for 10 hours. After conclusion of the reaction, the reaction solution was diluted with water, and the pH of the solution was lowered to 2 by dropping hydrochloric acid. The generated precipitate was collected, washed sufficiently with water, and dried, to obtain 10.8 g of the objective ether compound. (Yield: 89%)

来源