反应 #64082

反应方程式

(2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate

溶剂

water

反应条件

后处理

1. 1
   萃取followed by ether extraction
2. 2
   干燥The ether phase was dried over anhydrous sodium sulfate and ether
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

实验过程

To 1.0 g of (2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedure similar to Example 1-(4) were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol, stirred at room temperature for one hour, and 20 ml of water was added followed by ether extraction. The ether phase was dried over anhydrous sodium sulfate and ether was distilled off, and then the residue was subjected to distillation to obtain 0.4 g of isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate. ##STR41##

来源