反应 #64081

反应方程式

(2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate

溶剂

water

反应条件

后处理

1. 1
   萃取ether extraction
2. 2
   干燥After drying the ether phase over anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONthe ether was distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

实验过程

To 1.0 g of (2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedures similar to (1)-(4) of Example 1 were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol and stirred at room temperature for one hour, and 20 ml of water was added to effect ether extraction. After drying the ether phase over anhydrous sodium sulfate, the ether was distilled off and the residue was subjected to distillation to give 0.4 g of isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate. The NMR chart is shown in FIG. 6. ##STR31##

来源