反应 #640575

反应方程式

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

收率 99.3%

溶剂

ethanol

反应条件

后处理

1. 1
   温度to reflux for 1.5 hours
2. 2
   过滤the reaction mixture was filtered with suction
3. 3
   萃取extracted with ethyl acetate
4. 4
   洗涤The organic layer was washed with a saturated brine
5. 5
   干燥dried over anhydrous sodium sulfate

实验过程

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.59 g, 5.10 mmol), iron powder (1.42 g, 25.4 mmol), ammonium chloride (0.14 g, 2.62 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for 1.5 hours. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.43 g) was obtained by evaporating the solvent under reduced pressure.

来源