反应 #640539

反应方程式

2,6-Dimethylaniline

ethyl bromoacetate

N-(2,6-Dimethylphenyl)glycine hydrobromide salt

→

N-(2,6 Dimethylphenyl)glycine

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他A precipitated
2. 2
   其他formed which
3. 3
   其他was collected
4. 4
   其他triturated with dichloromethane (25 mL)

实验过程

2,6-Dimethylaniline (6.1 g, 50.4 mmol), and ethyl bromoacetate (8.4 g, 50.4 mmol) were refluxed neat for 10 min. The reaction mixture was cooled to room temperature and poured into dichloromethane (75 mL). A precipitated formed which was collected and triturated with dichloromethane (25 mL). N-(2,6-Dimethylphenyl)glycine hydrobromide salt (1.21 g, 4.6 mmol, 9.0%) was collected as a white crystalline solid. 1H NMR (CD3OD) d 2.48 (s, 6H), 4.29 (s, 2H), 7.00-7.10 (m, 3H).

来源