反应 #640523

反应方程式

diiodomethane

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

4-fluorophenol

→

title compound

4-[1-(4-Fluorophenoxymethyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

反应条件

后处理

1. 1
   其他Evaporation of the solvent under reduced pressure
2. 2
   其他partitioning of the resulting residue between water and ethyl acetate
3. 3
   干燥by drying of the organic solution over sodium sulphate and chromatography of the residue

实验过程

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) followed by 4-fluorophenol (0.0557 g, 0.497 mmol) and diiodomethane (0.133 g, 0.497 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 155-158° C.

来源