反应 #640517

反应方程式

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

溶剂

ethanol

反应条件

后处理

1. 1
   温度is refluxed for 20 hours
2. 2
   其他Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   其他by drying
4. 4
   其他evaporation of the solvent
5. 5
   其他gives the crude product
6. 6
   其他Purification by chromatography on silicagel

实验过程

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

来源