反应 #64042

反应方程式

3-hydroxy-5-mesityl-2-propionylcyclohex-2-en-1-one

chlorosulphonic acid

→

3-hydroxy-5-(2,4,6-trimethyl-3-chlorosulphonylphenyl)-2-propionylcyclohex-2-en-1-one

溶剂

chloroform

反应条件

后处理

1. 1
   萃取the aqueous phase was extracted with chloroform (50 ml)
2. 2
   干燥The organic phase was dried over anhydrous sodium sulphate
3. 3
   其他the solvent was removed by evaporation under reduced pressure
4. 4
   其他a rotary evaporator

实验过程

A solution of 3-hydroxy-5-mesityl-2-propionylcyclohex-2-en-1-one (1.8 g) in chloroform (20 ml) was stirred and cooled to 0° C. during the dropwise addition of chlorosulphonic acid (10 ml). The mixture was stirred for four hours at 20° C. and then poured into ice-water and the aqueous phase was extracted with chloroform (50 ml). The organic phase was dried over anhydrous sodium sulphate and the solvent was removed by evaporation under reduced pressure using a rotary evaporator. The product 3-hydroxy-5-(2,4,6-trimethyl-3-chlorosulphonylphenyl)-2-propionylcyclohex-2-en-1-one was isolated as a brown oil (2.4 g, 97%). Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 1.16 (3H, t); 2.47 (3H, s); 2.69 (3H, s); 2.80 (3H, s); 2.7-4.0 (7H, m); 7.05 (1H, s); 18.30 (1H, s).

来源