反应 #63871

反应方程式

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

溶剂

acetone

反应条件

后处理

1. 1
   温度The reaction mixture was cooled
2. 2
   过滤filtered
3. 3
   其他The solvent was removed by evaporation
4. 4
   温度the residue was heated
5. 5
   其他to remove unreacted 6-bromohexanenitrile

实验过程

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

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