反应 #635691

反应方程式

NBS

DMF

NBS

1b

1,2-di(2-ethylhexyloxy)benzene

→

4-bromo-1,2-di(2-ethylhexyloxy)benzene

溶剂

water

反应条件

后处理

1. 1
   洗涤The organic layer was washed with a saturated LiCl solution and water
2. 2
   干燥After drying with MgSO4 the solvent
3. 3
   其他was removed under reduced pressure
4. 4
   workup.DISTILLATIONThe remaining oil was distilled (160° C./0.01 mmHg)

实验过程

Solid NBS (26.21g, 0.147 mol) was added to an ice cold CH2Cl2 solution (250 mL) of 1b under N2 in the absence of light. Just enough DMF was added (30 mL) to dissolve the NBS. The reaction mixture was allowed to warm to room temperature and then stirred for 12 h. The mixture was then poured into water. The organic layer was washed with a saturated LiCl solution and water. After drying with MgSO4 the solvent was removed under reduced pressure. The remaining oil was distilled (160° C./0.01 mmHg) to yield 4-bromo-1,2-di(2-ethylhexyloxy)benzene (2b) in 96% yield a colorless oil.

来源