反应 #63472

反应方程式

2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

sodium carbonate

→

2-(3-pyridylmethyl)-6-acetylnaphthalene

收率 101.3%

溶剂

hydrochloric acid

反应条件

后处理

1. 1
   萃取extracted with methylene chloride
2. 2
   干燥The organic layer was dried over sodium sulfate
3. 3
   其他the solvent removed under reduced pressure

实验过程

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

来源