反应 #632040

反应方程式

3-aminopropylmethylphosphinic acid

compound ( 17 )

[(1-Isobutanoyloxyethoxy)carbonyloxy] Succinimide

→

title compound ( 111 )

3-{[1-Isobutanoyloxyethoxy]carbonylamino}propyl Methylphosphinic Acid

溶剂

acetonitrile

water

反应条件

后处理

1. 1
   其他The solvent was removed under reduced pressure
2. 2
   其他the residue was purified by preparative HPLC

实验过程

A solution of 3-aminopropylmethylphosphinic acid (137 mg, 1 mmol) and compound (17) (301 mg, 1 mmol) in acetonitrile (5 mL) and water (0.5 mL) was stirred at ambient temperature for 16 h. The solvent was removed under reduced pressure and the residue was purified by preparative HPLC to afford the title compound (111) as a white solid. 1H NMR (CDCl3, 400 MHz): δ 7.69 (br, 1H), 6.77 (q, 1H, J=5.2 Hz), 3.27 (t, 2H, J=6 Hz), 2.53 (m, 1H), 1.83-1.73 (m, 4H), 1.45 (m, 6H), 1.15 (d, 6H, J=7.2 Hz). MS (ESI) m/z 296.1 (M+H)+, 294.1 (M−H)−.

来源