反应 #632038

反应方程式

3-aminopropylphosphonous acid

sodium bicarbonate

compound ( 17 )

[(1-Isobutanoyloxyethoxy)carbonyloxy] Succinimide

→

title compound ( 31 )

3-{[1-Isobutanoyloxyethoxy]carbonylamino}propyl Phosphonous Acid

溶剂

diethyl ether

water

acetonitrile

反应条件

后处理

1. 1
   洗涤washed with 0.1 M aqueous potassium bisulfate (3×100 mL)
2. 2
   其他The organic phase is separated
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   过滤filtered
5. 5
   浓缩concentrated in vacuo

实验过程

To a solution of 3-aminopropylphosphonous acid (10 mmol) and sodium bicarbonate (20 mmol) in water (40 mL) is added a solution of compound (17) (10 mmol) in acetonitrile (20 mL) over 1 min. The reaction is stirred at ambient temperature for 16 h. The reaction mixture is diluted with diethyl ether (100 mL) and washed with 0.1 M aqueous potassium bisulfate (3×100 mL). The organic phase is separated, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to afford the title compound (31) as a white solid.

来源