反应 #632027

反应方程式

3-quinuclidinone

benzaldehyde

sodium hydroxide

→

(Z)-2-benzylidenequinuclidin-3-one

收率 91.2%

溶剂

ethanol

反应条件

后处理

1. 1
   温度was refluxed for 1.5 h
2. 2
   温度After the solution was cooled
3. 3
   其他the yellow precipitates
4. 4
   其他were collected
5. 5
   洗涤washed with ethanol
6. 6
   其他dried

实验过程

A mixture of 3-quinuclidinone (20.9 g, 167 mmol), benzaldehyde (17.7 g, 167 mmol), and one pellet of sodium hydroxide in 75 mL of ethanol was refluxed for 1.5 h. After the solution was cooled, the yellow precipitates were collected, washed with ethanol, and dried to give (Z)-2-benzylidenequinuclidin-3-one (32.5 g, yield: 91.2%, mp 130-132° C.).

来源