反应 #632010

反应方程式

N-tert-butyl-(1-methyl)cyclopropylsulfonamide

methyl benzoate

→

N-tert-butyl-(1-benzoyl)cyclopropyl-sulfonamide

收率 66.0%

反应条件

后处理

1. 1
   其他This compound was obtained in 66% yield
2. 2
   其他The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane

实验过程

This compound was obtained in 66% yield using the procedure described for the synthesis of N-tert-butyl-(1-methyl)cyclopropylsulfonamide using 1.2 equivalents of methyl benzoate as the electrophile. The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane: 1H NMR (CDCl3) δ 1.31 (s, 9H), 1.52 (m, 2H), 1.81 (m, 2H), 4.16 (br s, 1H), 7.46 (m, 2H), 7.57 (m, 1H), 8.05 (d, J=8.5 Hz, 2H).

来源