反应 #631998

反应方程式

product

(1S,2R) N-Boc-1-amino-2-vinylcyclopropane carboxylic acid ethyl ester

HCl dioxane

→

(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester hydrochloride

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated

实验过程

The product of Step 2 (9.39 g, 36.8 mmol) was dissolved in 4N HCl/dioxane (90 mL, 360 mmol) and was stirred for 2 hours at room temperature. The reaction mixture was concentrated to provide (1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester hydrochloride in quanitative yield (7 g, 100%). 1H NMR (methanol-d4) δ 1.32 (t, J=7.1, 3H), 1.72 (dd, J=10.2, 6.6 Hz, 1H), 1.81 (dd, J=8.3, 6.6 Hz, 1H), 2.38 (q, J=8.3 Hz, 1H), 4.26-4.34 (m, 2H), 5.24 (dd, 10.3, 1.3 Hz, 1H) 5.40 (d, J=17.2, 1H), 5.69-5.81 (m, 1H).

来源