反应 #6317

反应方程式

hydrochloric acid

2-aminobenzonitrile

cyclohexanone

hydrochloric acid

→

9-amino-1,2,3,4-tetrahydroacridine hydrate

收率 67.0%

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux for 3 days
3. 3
   其他The precipitate was collected
4. 4
   洗涤washed with 10% hydrochloric acid

实验过程

A mixture of 2-aminobenzonitrile (120 g), cyclohexanone (115.8 ml), conc hydrochloric acid (9.2 ml), and cuprous chloride (1.21 g) was heated under reflux for 3 days, with stirring. At the end of each 24 hr period, additional cuprous chloride (1.21 g) was added. At the end of the 3rd day, additional conc hydrochloric acid (47.3 ml) was added, and the mixture was cooled to ambient temperature. The precipitate was collected and washed with 10% hydrochloric acid to provide 160 g (67.0%) of 9-amino-1,2,3,4-tetrahydroacridine hydrate, mp 180°-185°.

来源