反应 #63131

反应方程式

hydrochloric acid

3-tetradecylphenol

acetate

aluminum chloride

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)ethanone

溶剂

ether

反应条件

后处理

1. 1
   温度to cool
2. 2
   萃取extracted several times with ether
3. 3
   洗涤washed with water, brine
4. 4
   其他dried
5. 5
   其他The crude material was chromatographed on silica gel
6. 6
   洗涤eluting with hexane:ethyl acetate (50:1)

实验过程

A 20 g portion of 3-tetradecylphenol, acetate was heated at 110° C. and 8.4 g of aluminum chloride was added in portions over a 3 hour period. The mixture was allowed to cool, then diluted with ether, poured onto ice containing 10 ml of concentrated hydrochloric acid and extracted several times with ether. The ether extracts were combined, washed with water, brine and dried. The crude material was chromatographed on silica gel, eluting with hexane:ethyl acetate (50:1), giving 15.8 g of the desired compound, mp 45°-46° C.

来源