反应 #63115

反应方程式

4-tetradecylphenol

acetate

aluminum trichloride

→

desired compound

1-(2-Hydroxy-5-tetradecylphenyl)ethanone

溶剂

chloroform

反应条件

后处理

1. 1
   温度the mixture was heated at this temperature for 45 minutes
2. 2
   温度The mixture was then cooled
3. 3
   洗涤washed with 50% aqueous hydrochloric acid
4. 4
   干燥water and dried
5. 5
   其他The solvents were removed
6. 6
   其他the residue recrystallized from ether-methanol

实验过程

A 900 mg portion of 4-tetradecylphenol, acetate was heated at 70° C. under argon and 720 mg of aluminum trichloride was added portionwise. After 2 hours the temperature was raised to 120° C. and the mixture was heated at this temperature for 45 minutes. The mixture was then cooled, diluted with chloroform, washed with 50% aqueous hydrochloric acid then water and dried. The solvents were removed and the residue recrystallized from ether-methanol, giving 850 mg of the desired compound, mp 38.5°-39.5° C.

来源