反应 #63057

反应方程式

2,2,2-trifluoroethylisothiocyanate

4-amino-2-(4-phthalimidobutylthio)pyrimidine

2,2,2-trifluoroethylisothiocyanate

→

4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutylthio)pyrimidine

收率 69.9%

溶剂

acetonitrile

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture stirred at 70° for 48 hours
2. 2
   温度The reaction mixture was cooled
3. 3
   过滤filtered
4. 4
   workup.STIRRINGthe residue stirred with N aqueous acetic acid
5. 5
   其他the undissolved solid collected

实验过程

A mixture of 4-amino-2-(4-phthalimidobutylthio)pyrimidine (0.49 g.), acetonitrile (5 ml.) and 2,2,2-trifluoroethylisothiocyanate (0.28 g.) was stirred at 70° for 48 hours. A further 0.28 g. of 2,2,2-trifluoroethylisothiocyanate was added and the mixture stirred at 70° for 48 hours. The reaction mixture was cooled and filtered, the residue stirred with N aqueous acetic acid and the undissolved solid collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutylthio)pyrimidine (0.49 g.), m.p. 201°-202° after recrystallisation from a mixture of ethanol and dimethylformamide.

来源