反应 #630321

反应方程式

2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

triethylamine

2-chloroethylisothiocyanate

→

title compound

4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-(2-thiazolin-2-ylamino)ethoxymethyl]-1,4-dihydropyridine

溶剂

methylene chloride

反应条件

后处理

1. 1
   洗涤The mixture was then washed with water (5 ml)
2. 2
   其他dried
3. 3
   过滤filtered
4. 4
   其他evaporated
5. 5
   其他to give a gum
6. 6
   洗涤Chromatography of the gum on silica "Kieselgel 60H" (Trade Mark) eluting initially with toluene

实验过程

2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (0.5 g), triethylamine (0.3 ml) and 2-chloroethylisothiocyanate (0.16 ml) were dissolved in methylene chloride (5 ml) and the mixture was stirred at room temperature for 2 hours. The mixture was then washed with water (5 ml), dried, filtered and evaporated to give a gum. Chromatography of the gum on silica "Kieselgel 60H" (Trade Mark) eluting initially with toluene then with chloroform with a trace of methanol gave the title compound, which was recrystallized from ether, yield 0.102 g, m.p. 145°-147°.

来源