反应 #6287

反应方程式

4-hydroxymethyl-2-methoxy-2-phenyl-1,3-dioxolane

triethylamine

acryloyl chloride

→

4-acryloyloxymethyl-2-methoxy-2-phenyl-1,3-dioxolane

溶剂

methylene chloride

反应条件

后处理

1. 1
   其他The crude product was purified by column chromatography over basic alumina

实验过程

The procedure of Example A was repeated, employing 21 grams (100 mmol.) of 4-hydroxymethyl-2-methoxy-2-phenyl-1,3-dioxolane, 25.3 grams (250 mmol.) of triethylamine, 9.5 grams (105 mmol.) of acryloyl chloride and 150 ml. of methylene chloride. The crude product was purified by column chromatography over basic alumina, using 15% (by volume) ethyl acetate in hexane as an eluant, to yield the desired 4-acryloyloxymethyl-2-methoxy-2-phenyl-1,3-dioxolane.

来源