反应 #624815

反应方程式

2-(ethyl(phenyl)amino)ethanol

1,2-napthoquinone-4-sulfonic acid sodium salt

water

→

4-(4-(ethyl(2-hydroxyethyl)amino)phenyl)naphthalene-1,2-dione

溶剂

MeOH

反应条件

后处理

1. 1
   温度The mixture was then cooled
2. 2
   其他the MeOH removed in vacuo
3. 3
   过滤the resulting suspension filtered
4. 4
   洗涤The precipitate was then washed with water and oven
5. 5
   其他dried at 50° C.

实验过程

A suspension of 1,2-napthoquinone-4-sulfonic acid sodium salt (10.5 g, 40.35 mmol) in a 9:1 mixture of water:MeOH (250 ml) was treated in one portion with 2-(ethyl(phenyl)amino)ethanol (6.67 g, 40.35 mmol) and stirred at 50° C. for 18 hrs. The mixture was then cooled, the MeOH removed in vacuo and the resulting suspension filtered. The precipitate was then washed with water and oven dried at 50° C. to give the product, 4-(4-(ethyl(2-hydroxyethyl)amino)phenyl)naphthalene-1,2-dione, as a dark purple solid (6.8 g, 54%). Analysis of the product by 1H NMR gave a spectrum consistent with the structure.

来源