反应 #624524

ord-768546c6d2434d21a6bc02483ce6f7d9

反应方程式

CC1(C)[C@@H]2[C@@H](C#N)NC[C@@H]21
(1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
COC(=O)[C@H]1NC[C@H]2[C@@H]1C2(C)C
(1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester
→
COC(=O)C1NCC2C1C2(C)C
6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid Methyl Ester

反应物

CC1(C)[C@@H]2[C@@H](C#N)NC[C@@H]21
(1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
COC(=O)[C@H]1NC[C@H]2[C@@H]1C2(C)C
(1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

The (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile prepared according to Example 16 or 17 is converted to the corresponding substantially enantiomerically pure (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester by the procedure described in PCT International Application Publication WO 2007/075790.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08859784B2uspto-grants-2014_10