反应 #623924

反应方程式

water

2,2-dimethyl-thiirane

N-butyl-cyanamide

potassium carbonate

→

title compound

收率 66.6%

3-butyl-5,5-dimethylthiazolidin-2-imine

收率 66.6%

溶剂

2-butanone

反应条件

后处理

1. 1
   萃取extracted twice with ethyl acetate
2. 2
   干燥The combined organic extracts were dried over Na2SO4
3. 3
   过滤filtered
4. 4
   浓缩concentrated under reduced pressure

实验过程

A mixture of 2,2-dimethyl-thiirane (TCI, 1.5 g, 17 mmol), N-butyl-cyanamide (1.7 g, 17 mmol) (prepared as described in Ross J. Med. Chem. 1979, 22; 412) and potassium carbonate (2.4 g, 17 mmol) in 2-butanone (15 mL) was heated to 80° C. overnight. The mixture was poured into water, and extracted twice with ethyl acetate. The combined organic extracts were dried over Na2SO4, filtered, concentrated under reduced pressure to afford 2.11 g of the title compound.

来源