反应 #62309

反应方程式

4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

3-fluorostyrene

water

→

title compound

2-[(E)-2-(3-Fluorophenyl)-vinyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

溶剂

toluene

反应条件

后处理

1. 1
   干燥dried over anhydrous magnesium sulfate
2. 2
   其他The solvent was evaporated
3. 3
   其他the resultant crude product was purified
4. 4
   其他separated by silica gel column chromatography (diethyl ether:n-hexane=1:19)

实验过程

To a solution of 11 mg of chloro(1,5-cyclooctadiene)-rhodium(I) dimer and 0.61 mL of 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in 15 mL toluene was added dropwise 1.0 mL of 3-fluorostyrene, and stirred at room temperature for 4 hours. The reaction solution was added with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resultant crude product was purified and separated by silica gel column chromatography (diethyl ether:n-hexane=1:19), to afford 311 mg of the title compound as a pale yellow oil.

来源