反应 #622777

反应方程式

product

2-amino-4-morpholinophthalazin-1(2H)-one

2-(1,3-benzodioxol-5-yl)acetic acid

→

title compound

2-(1,3-benzodioxol-5-yl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

反应条件

实验过程

The product of Example 1B and 2-(1,3-benzodioxol-5-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 6.96 (d, J=1.7 Hz, 1H), 6.89 (d, J=7.9 Hz, 1H), 6.84 (dd, J=7.9, 1.7 Hz, 1H), 6.00 (s, 2H), 3.81-3.83 (m, 4H), 3.58 (s, 2H), 3.08-3.10 (m, 4H); MS (ESI+) M/Z 409 (M+H)+.

来源