反应 #619182

反应方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

lithium borohydride

→

desired compound

收率 97.0%

1,1-Dicyclohexyl-3-(5-hydroxymethyl-thiazol-2-yl)-urea

收率 97.0%

溶剂

MeOH

反应条件

后处理

1. 1
   其他Prepared
2. 2
   其他Purification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2)

实验过程

Prepared using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (50 mg, 0.15 mmol) and lithium borohydride (95 μL, 2M in THF) in MeOH (1 mL). Purification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2) afforded 49 mg (97%) of the desired compound.

来源