反应 #619173

反应方程式

5-formyl-2-aminothiazole

4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester

CDI

→

desired product

4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester

溶剂

THF

反应条件

后处理

1. 1
   其他Prepared in a manner similar to general procedure (C)

实验过程

Prepared in a manner similar to general procedure (C) using 5-formyl-2-aminothiazole (1.88 g, 14.6 mmol), 4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.32 mg, 14.6 mmol), catalytic DMAP, CDI (2.60 g, 1.1 mmol) and THF with heating to 65° C. afforded 1.77 g (27%) of the desired product after purification.

来源