反应 #619169

反应方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

piperazine-1-sulfonic acid dimethyl amide hydrochloride

sodium triacetoxyborohydride

→

desired product

收率 42.1%

4-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-piperazine-1-sulfonic acid dimethylamide

收率 42.1%

反应条件

后处理

1. 1
   其他Prepared

实验过程

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (84 mg, 0.25 mmol), piperazine-1-sulfonic acid dimethyl amide hydrochloride (115 mg, 0.50 mmol) and sodium triacetoxyborohydride (70 mg, 0.33 mmol) to afford 54 mg (42%) of the desired product after purification.

来源