反应 #619166

反应方程式

1,1-dicyclohexyl-3-(5-piperazin-1-ylmethyl-thiazol-2-yl)-urea hydrochloride

DIEA

alpha-toluenesulfonyl chloride

→

desired product

收率 29.0%

1,1-Dicyclohexyl-3-[5-(4-phenylmethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

收率 29.0%

反应条件

后处理

1. 1
   其他Prepared

实验过程

Prepared as described in general procedure (Q) using 1,1-dicyclohexyl-3-(5-piperazin-1-ylmethyl-thiazol-2-yl)-urea hydrochloride (26 mg, 0.05 mmol), DIEA (26 μL, 0.15 mmol) and alpha-toluenesulfonyl chloride (20 mg. 0.10 mmol) to afford 8 mg (29%) of the desired product after purification.

来源