反应 #619162

反应方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

1-propanesulfonyl-piperazine hydrochloride

sodium triacetoxyborohydride

→

desired product

收率 27.4%

1,1-Dicyclohexyl-3-{5-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-thiazol-2-yl}-urea

收率 27.4%

反应条件

后处理

1. 1
   其他Prepared

实验过程

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (50 mg, 0.15 mmol), 1-propanesulfonyl-piperazine hydrochloride (52 mg, 0.23 mmol) and sodium triacetoxyborohydride (48 mg. 0.23 mmol) to afford 21 mg (27%) of the desired product after purification.

来源