反应 #619150

反应方程式

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester

Hydrogen chloride

→

desired compound

收率 76.0%

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid

收率 76.0%

溶剂

methylene chloride

diethyl ether

反应条件

后处理

1. 1
   浓缩concentrated
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in a minimum amount of methylene chloride
3. 3
   其他precipitated with diethyl ether
4. 4
   其他decanted

实验过程

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester (14 mg, 0.03 mmol) was dissolved in methylene chloride. Hydrogen chloride (100 μL, 4N in dioxane) was added and the reaction was stirred at ambient temperature until no ester could be detected. The reaction was diluted with diethyl ether and concentrated. The resulting residue was dissolved in a minimum amount of methylene chloride, precipitated with diethyl ether and decanted. This was repeated to afford 9 mg (69%) of the desired compound. HPLC-MS: m/z 395 (M+1).

来源