反应 #619131

ord-eda29a4ef9e24933ae23abe892dc11cd

反应方程式

CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester
C[C@H]1CC[C@H](NC2CCCCCC2)CC1
cycloheptyl-(trans-4-methyl-cyclohexyl)-amine
→
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCCCC2)CC1
title compound
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCCCC2)CC1
{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid

反应物

CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester
—
( B )
C[C@H]1CC[C@H](NC2CCCCCC2)CC1
cycloheptyl-(trans-4-methyl-cyclohexyl)-amine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他Hydrolysis

实验过程

{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cycloheptyl-(trans-4-methyl-cyclohexyl)-amine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: USRE045183E1uspto-grants-2014_10