反应 #619124

ord-87100a33b1144e2ba845f52272eff936

反应方程式

CI
methyliodide
CCCC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCC(C)CC2)CC1
1-(1-butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
→
CCCC(=O)N1CCC(N(C(=O)Nc2ncc(SC)s2)C2CCCCC2)CC1
1-(1-Butyryl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea

反应物

CI
methyliodide
—
( I )
CCCC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCC(C)CC2)CC1
1-(1-butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他Prepared

实验过程

Prepared as described in general procedure (II) and (I) using 1-(1-butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and methyliodide.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: USRE045183E1uspto-grants-2014_10