反应 #619117

反应方程式

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

收率 47.7%

溶剂

methanol

反应条件

后处理

1. 1
   其他The content was degassed
2. 2
   过滤The mixture was filtered through celite
3. 3
   浓缩the filtrate was concentrated
4. 4
   其他The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

实验过程

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

来源