反应 #619083

反应方程式

Dicyclohexylamine

aminothiazole

carbonyldiimidazole

→

title product

1,1-Dicyclohexyl-3-thiazol 2 yl urea

溶剂

ethyl acetate

dichloromethane

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction stirred overnight at room temperature
2. 2
   洗涤washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
3. 3
   干燥dried over magnesium sulphate
4. 4
   浓缩concentrated in vacuo
5. 5
   其他the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min)

实验过程

To a solution of aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and the solution stirred 2 h at room temperature. Dicyclohexylamine (1 eq) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min) to give the title product (52 mg).

来源