反应 #61793

反应方程式

water

5-Chloromethyl-2-(4-chloro-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

收率 69.0%

2-(4-Chloro-phenyl)-5-[4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

收率 69.0%

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued over night
3. 3
   其他the precipitate was isolated
4. 4
   洗涤washed thoroughly with water, methanol/water 1:1 and diisopropylether
5. 5
   其他The residue was dried at 40° C.

实验过程

A solution of 91 mg (0.42 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 18 mg (0.44 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 100 mg (0.42 mmol) 5-Chloromethyl-2-(4-chloro-phenyl)-pyridine (GB 1147068) were added and stirred continued over night. After addition of 8 ml water, the precipitate was isolated, washed thoroughly with water, methanol/water 1:1 and diisopropylether. The residue was dried at 40° C. to give 121 mg (69%) of the title compound as light brown powder.

来源