反应 #61350

ord-2d76968ec6ee4485b6994ef87c320c1b

反应方程式

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

Brc1ccccc1CNC1CC1

(2-bromobenzyl)cyclopropylamine

→

CC(=O)N1C[C@H]2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)N(Cc3ccccc3Br)C3CC3)[C@@H](C1)N2.O=CO

(rac.)-(1R*,5S*)-3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid (2-bromobenzyl)cyclopropylamide formate salt

反应物

3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

(2-bromobenzyl)cyclopropylamine

试剂

无

反应条件

详细条件

See reaction.notes.procedure_details.

后处理

1
其他Synthesized

实验过程

Synthesized according to typical procedures H and E from bicyclononene BN10 and (2-bromobenzyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 684.11.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07427613B2uspto-grants-2008_09