反应 #61166

反应方程式

1-(5-methoxy-2-nitro-phenyl)-piperidine

→

title compound

收率 98.0%

4-Methoxy-2-piperidin-1-yl-phenylamine

收率 98.0%

溶剂

MeOH

反应条件

后处理

1. 1
   过滤The reaction was filtered through Celite
2. 2
   浓缩concentrated in vacuo

实验过程

1-(5-methoxy-2-nitro-phenyl)-piperidine (80 mg, 0.33 mmol, as prepared in the previous step) was stirred with 55 mg of 5% Pd—C in MeOH (4 mL) under H2 balloon pressure for 2 h. The reaction was filtered through Celite and concentrated in vacuo to afford 67 mg (98%) of the title compound as a reddish solid, which was used immediately without further purification. Mass spectrum (ESI, m/z): Calcd. for C12H18N2O, 207.1 (M+H), found 207.2.

来源