反应 #61158

反应方程式

N-[1-(2-nitro-phenyl)-piperidin-4-yl]-acetamide

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title compound

收率 100.0%

N-[1-(2-Amino-phenyl)-piperidin-4-yl]-acetamide

收率 100.0%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The mixture was filtered through a short column of Celite
2. 2
   其他the solvent removed in vacuo

实验过程

To a solution of N-[1-(2-nitro-phenyl)-piperidin-4-yl]-acetamide (as prepared in the previous step) (55 mg, 0.21 mmol) in methanol (10 mL) was added 10% palladium on carbon (50 mg) and the mixture stirred at RT for 1 h under hydrogen (1 atm). The mixture was filtered through a short column of Celite and the solvent removed in vacuo to yield 48 mg (100%) of the title compound as a purple solid. 1H-NMR (400 MHz, CDCl3): δ 6.82-6.67 (m, 4H), 4.44 (m, 1H), 3.78 (m, 1H), 3.35 (br s, 2H), 3.21 (m, 1H), 2.91 (m, 1H), 2.11 (s, 3H), 2.12-2.04 (m, 2H), 1.75 (br s, 1H), 1.41 (m, 2H). LC-MS (ESI, m/z): Calcd. for C13H20N3O, 234.2 (M+H); found: 234.0.

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