反应 #61051

反应方程式

triethylamine

trifluoroacetamidine

((Z)-2-Chloro-3-dimethylamino-allylidene)-dimethyl-ammonium hexafluoro phosphate

→

title compound

5-Chloro-2-trifluoromethyl-pyrimidine

溶剂

acetonitrile

反应条件

后处理

1. 1
   workup.ADDITIONpoured onto water
2. 2
   萃取extracted 3 times with ether
3. 3
   干燥The combined extracts were dried over sodium sulfate
4. 4
   过滤filtered
5. 5
   workup.DISTILLATIONdistilled at 760 mm Hg

实验过程

To a solution of 38 mmol trifluoroacetamidine in 70 ml acetonitrile was added 37.92 mmol ((Z)-2-Chloro-3-dimethylamino-allylidene)-dimethyl-ammonium hexafluoro phosphate (CAS: 291756-76-8) followed by 45.5 mmol triethylamine. The yellow solution was stirred at room temperature for 5 hours, then poured onto water and extracted 3 times with ether. The combined extracts were dried over sodium sulfate, filtered and distilled at 760 mm Hg to provide the title compound. MS (m/e): 182.2 (M+, 100%)

来源