反应 #60884

反应方程式

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine

Intermediate 91

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine

5-tributylstannyl-4-iodo-1-methyl-1H-imidazole

Intermediate 92

5-tributylstannyl-4-iodo-1-methyl-1H-imidazole

→

title compound

收率 67.3%

6-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-methylthio-thieno[2,3-d]pyrimidine

收率 67.3%

溶剂

DMF

反应条件

后处理

1. 1
   其他degassed with nitrogen for 10 min
2. 2
   浓缩The reaction mixture was concentrated in vacuo
3. 3
   其他the crude product triturated with DCM (20 mL)

实验过程

4-Methylthio-6-iodo-thieno[2,3-d]pyrimidine (Intermediate 91) (949 mg), 5-tributylstannyl-4-iodo-1-methyl-1H-imidazole (Intermediate 92) (2.76 g) and tetrakis(triphenylphosphine)palladium(0) (178 mg) were stirred in anhydrous DMF (50 mL), degassed with nitrogen for 10 min, then heated to 100° C. for 18 hours under an inert atmosphere. The reaction mixture was concentrated in vacuo and the crude product triturated with DCM (20 mL) to afford the title compound as a yellow solid (805 mg, 67%);

来源