反应 #607493

反应方程式

4-bromo-2-fluorobenzoic acid

oxalyl chloride

DMF

→

4-bromo-2-fluorobenzoyl chloride

收率 100.1%

溶剂

DCM

反应条件

后处理

1. 1
   浓缩The mixture was concentrated under reduced pressure

实验过程

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

来源