反应 #607487

反应方程式

137g

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

oxalyl chloride

DMF

→

3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

收率 92.5%

溶剂

DCM

反应条件

后处理

1. 1
   其他Upon reaction completion
2. 2
   浓缩the mixture was concentrated

实验过程

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

来源